5E1S
The Crystal structure of INSR Tyrosine Kinase in complex with the Inhibitor BI 885578
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Insulin receptor | polymer | 308 | 34951.9 | 1 | UniProt (P06213) Pfam (PF07714) In PDB | Homo sapiens (Human) | IR |
| 2 | A | (5R)-N-(1-{2-[4-(2-methoxyethyl)piperazin-1-yl]ethyl}-1H-pyrazol-3-yl)-5,8-dimethyl-9-phenyl-6,8-dihydro-5H-pyrazolo[3,4-h]quinazolin-2-amine | non-polymer | 527.7 | 1 | Chemie (5JA) | |||
| 3 | water | water | 18.0 | 137 | Chemie (HOH) |
Sequence modifications
A: 978 - 1283 (UniProt: P06213)
| PDB | External Database | Details |
|---|---|---|
| Gly 976 | - | expression tag |
| Ser 977 | - | expression tag |
| Ser 981 | Cys 1008 | conflict |
| Asn 1132 | Asp 1159 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34951.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 527.7 | |
| All* | Total formula weight | 35479.6 |
