5E0G
1.20 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic (17-mer) inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Norovirus 3C-like protease | polymer | 188 | 20126.1 | 1 | UniProt (Q83883) | Norwalk virus (Hu/NV/NV/1968/US) | |
| 2 | B (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 3 | C (A) | (phenylmethyl) ~{N}-[(8~{S},11~{S},14~{S})-8-(hydroxymethyl)-11-(2-methylpropyl)-5,10,13-tris(oxidanylidene)-1,4,9,12,17,18-hexazabicyclo[14.2.1]nonadeca-16(19),17-dien-14-yl]carbamate | non-polymer | 543.6 | 1 | BIRD (PRD_002201) Chemie (5LG) | |||
| 4 | D (A) | water | water | 18.0 | 165 | Chemie (HOH) |
Sequence modifications
A: 1 - 181 (UniProt: Q83883)
| PDB | External Database | Details |
|---|---|---|
| Met -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 20126.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 579.1 | |
| All* | Total formula weight | 20705.2 |
