5DXG
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-P5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Estrogen receptor | polymer | 261 | 29912.4 | 2 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | C, D (C, D) | Stapled Peptide SRC2-P5 | polymer | 13 | 1439.7 | 2 | UniProt (by SIFTS) (Q15596) | Homo sapiens | |
| 3 | E, F (A, B) | ESTRADIOL | non-polymer | 272.4 | 2 | Chemie (EST) | |||
| 4 | G, H (B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 382 | Chemie (HOH) |
Sequence modifications
A, B: 297 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Met 294 | - | initiating methionine |
| Asp 295 | - | expression tag |
| Pro 296 | - | expression tag |
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62704.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 729.0 | |
| All* | Total formula weight | 63433.2 |
