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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5DX3

Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-P3 and Estradiol

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Estrogen receptorpolymer26129774.11UniProt (P03372)
Pfam (PF00104)		Homo sapiens (Human)ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1
2B
(B)		Estrogen receptorpolymer26129802.21UniProt (P03372)
Pfam (PF00104)		Homo sapiens (Human)ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1
3C, D
(C, D)		Stapled Peptide SRC2-P3polymer131429.72UniProt (Q15596)Homo sapiens
4E, G
(A, B)		ESTRADIOLnon-polymer272.42Chemie (EST)
PubChem (16757676)
PubChem (1807201)
PubChem (450)
PubChem (177015577)
PubChem (5757)
PubChem (5998)
PubChem (10596)
PubChem (14880)
PubChem (43912931)
PubChem (44284023)
PubChem (68570)
PubChem (46781508)
PubChem (54403267)
PubChem (56624791)
PubChem (57041922)
PubChem (58650893)
PubChem (59084698)
PubChem (1807200)
PubChem (68014581)
PubChem (68209947)
PubChem (70220248)
PubChem (70864205)
PubChem (667480)
PubChem (667515)
PubChem (721867)
PubChem (928284)
PubChem (1258565)
PubChem (5317221)
PubChem (91740223)
PubChem (5317222)
PubChem (5745505)
PubChem (6328313)
PubChem (6432565)
PubChem (6560352)
PubChem (6603846)
PubChem (101691329)
PubChem (6918968)
PubChem (6919041)
PubChem (7000012)
PubChem (7004689)
PubChem (7048584)
PubChem (7048670)
PubChem (118548795)
PubChem (7061189)
PubChem (7067800)
PubChem (9795489)
PubChem (9811784)
PubChem (9903595)
PubChem (9938293)
PubChem (12313788)
PubChem (11869602)
PubChem (11870431)
PubChem (12313787)
PubChem (12313791)
PubChem (12313794)
PubChem (162947701)
PubChem (166849971)
PubChem (126969992)
PubChem (129010410)
PubChem (129317336)
PubChem (130307439)
PubChem (130307440)
PubChem (143489158)
PubChem (144605119)
PubChem (145157829)
PubChem (145610824)
PubChem (154109755)
PubChem (172873304)
5F
(A)		CHLORIDE IONnon-polymer35.51Chemie (CL)
PubChem (312)
6H, I, J, K
(A, B, C, D)		waterwater18.0140Chemie (HOH)
Sequence modifications
A: 297 - 554 (UniProt: P03372)
PDBExternal DatabaseDetails
Met 294-initiating methionine
Asp 295-expression tag
Pro 296-expression tag
Ser 537Tyr 537engineered mutation
B: 297 - 554 (UniProt: P03372)
PDBExternal DatabaseDetails
Met 294-initiating methionine
Asp 295-expression tag
Pro 296-expression tag
Met 417Cys 417conflict
Ser 537Tyr 537engineered mutation
C, D: 2 - 12 (UniProt: Q15596)
PDBExternal DatabaseDetails
Ace 1-expression tag
5gm 4Ile 689conflict
Nh2 13-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight62435.8
Non-Polymers*Number of molecules3
Total formula weight580.2
All*Total formula weight63016.0
*Water molecules are not included.

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PDB entries from 2026-05-06

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