5DX3
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-P3 and Estradiol
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Estrogen receptor | polymer | 261 | 29774.1 | 1 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
2 | B | Estrogen receptor | polymer | 261 | 29802.2 | 1 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
3 | C, D | Stapled Peptide SRC2-P3 | polymer | 13 | 1429.7 | 2 | UniProt (Q15596) In PDB | Homo sapiens | |
4 | A, B | ESTRADIOL | non-polymer | 272.4 | 2 | Chemie (EST) | |||
5 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
6 | water | water | 18.0 | 140 | Chemie (HOH) |
Sequence modifications
A: 297 - 554 (UniProt: P03372)
B: 297 - 554 (UniProt: P03372)
C, D: 2 - 12 (UniProt: Q15596)
PDB | External Database | Details |
---|---|---|
Met 294 | - | initiating methionine |
Asp 295 | - | expression tag |
Pro 296 | - | expression tag |
Ser 537 | Tyr 537 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met 294 | - | initiating methionine |
Asp 295 | - | expression tag |
Pro 296 | - | expression tag |
Met 417 | Cys 417 | conflict |
Ser 537 | Tyr 537 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ace 1 | - | expression tag |
5gm 4 | Ile 689 | conflict |
Nh2 13 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 62435.8 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 580.2 | |
All* | Total formula weight | 63016.0 |