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5DRM

Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a dichloro-substituted, 2,5-diarylthiophene-core ligand 4,4'-thiene-2,5-diylbis(3-chlorophenol)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BEstrogen receptorpolymer25729299.52UniProt (P03372)
Pfam (PF00104)
In PDB
Homo sapiens (Human)ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1
2C, DNuclear receptor coactivator 2polymer141666.92UniProt (Q15596)
In PDB
Homo sapiensNCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2
3A, B4,4'-thiene-2,5-diylbis(3-chlorophenol)non-polymer337.22Chemie (5ET)
4waterwater18.0253Chemie (HOH)
Sequence modifications
A, B: 298 - 554 (UniProt: P03372)
PDBExternal DatabaseDetails
Ser 537Tyr 537engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight61933.0
Non-Polymers*Number of molecules2
Total formula weight674.4
All*Total formula weight62607.4
*Water molecules are not included.

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PDB entries from 2024-04-24

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