5DR6

Aurora A Kinase in Complex with AA30 and JNJ-7706621 in Space Group P6122

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Aurora kinase A	polymer	273	31807.5	1	UniProt (O14965) Pfam (PF00069) In PDB	Homo sapiens (Human)	Aurora 2,Aurora/IPL1-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A
2	A	2-(3-bromophenyl)quinoline-4-carboxylic acid	non-polymer		328.2	1	Chemie (5E1)
3	A	4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide	non-polymer		394.4	1	Chemie (SKE)
4		water	water		18.0	11	Chemie (HOH)

Sequence modifications

A: 126 - 390 (UniProt: O14965)

PDB	External Database	Details
Met 124	-	initiating methionine
Gly 125	-	expression tag
Ala 287	Thr 287	engineered mutation
His 391	-	expression tag
His 392	-	expression tag
His 393	-	expression tag
His 394	-	expression tag
His 395	-	expression tag
His 396	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	31807.5
Non-Polymers*	Number of molecules	2
	Total formula weight	722.5
All*	Total formula weight	32530.0

*Water molecules are not included.