5DPV
Aurora A Kinase in Complex with AA35 and JNJ-7706621 in Space Group P6122
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Aurora kinase A | polymer | 273 | 31807.5 | 1 | UniProt (O14965) Pfam (PF00069) In PDB | Homo sapiens (Human) | Aurora 2,Aurora/IPL1-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A |
2 | A | 2-(3-bromophenyl)-8-fluoroquinoline-4-carboxylic acid | non-polymer | 346.2 | 1 | Chemie (5DN) | |||
3 | A | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide | non-polymer | 394.4 | 1 | Chemie (SKE) | |||
4 | water | water | 18.0 | 37 | Chemie (HOH) |
Sequence modifications
A: 126 - 390 (UniProt: O14965)
PDB | External Database | Details |
---|---|---|
Met 124 | - | initiating methionine |
Gly 125 | - | expression tag |
Ala 287 | Thr 287 | engineered mutation |
His 391 | - | expression tag |
His 392 | - | expression tag |
His 393 | - | expression tag |
His 394 | - | expression tag |
His 395 | - | expression tag |
His 396 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 31807.5 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 740.5 | |
All* | Total formula weight | 32548.0 |