5DOS
Aurora A Kinase in Complex with AA35 and ATP in Space Group P6122
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Aurora kinase A | polymer | 273 | 31807.5 | 1 | UniProt (O14965) Pfam (PF00069) In PDB | Homo sapiens (Human) | Aurora 2,Aurora/IPL1-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A |
| 2 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 3 | A | 2-(3-bromophenyl)-8-fluoroquinoline-4-carboxylic acid | non-polymer | 346.2 | 1 | Chemie (5DN) | |||
| 4 | A | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) |
Sequence modifications
A: 126 - 390 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Met 124 | - | initiating methionine |
| Gly 125 | - | expression tag |
| Ala 287 | Thr 287 | engineered mutation |
| His 391 | - | expression tag |
| His 392 | - | expression tag |
| His 393 | - | expression tag |
| His 394 | - | expression tag |
| His 395 | - | expression tag |
| His 396 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31807.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 877.6 | |
| All* | Total formula weight | 32685.2 |
