5DO7

Crystal Structure of the Human Sterol Transporter ABCG5/ABCG8

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, C)	ATP-binding cassette sub-family G member 5	polymer	666	74509.4	2	UniProt (Q9H222) Pfam (PF00005) Pfam (PF19055) Pfam (PF01061)	Homo sapiens (Human)	Sterolin-1
2	B, C (B, D)	ATP-binding cassette sub-family G member 8	polymer	685	76985.8	2	UniProt (Q9H221) Pfam (PF00005) Pfam (PF19055) Pfam (PF01061)	Homo sapiens (Human)	Sterolin-2

Sequence modifications

A, C: 1 - 651 (UniProt: Q9H222)

PDB	External Database	Details
Glu 2	Gly 2	engineered mutation
Gly 652	-	expression tag
Ser 653	-	expression tag
His 654	-	expression tag
His 655	-	expression tag
His 656	-	expression tag
His 657	-	expression tag
His 658	-	expression tag
His 659	-	expression tag
Gly 660	-	expression tag
His 661	-	expression tag
His 662	-	expression tag
His 663	-	expression tag
His 664	-	expression tag
His 665	-	expression tag
His 666	-	expression tag

B, D: 2 - 673 (UniProt: Q9H221)

PDB	External Database	Details
Met -1	-	initiating methionine
Gly 0	-	expression tag
Ser 1	-	expression tag
Ala 674	-	expression tag
Ser 675	-	expression tag
Asn 676	-	expression tag
Ser 677	-	expression tag
Leu 678	-	expression tag
Glu 679	-	expression tag
Val 680	-	expression tag
Leu 681	-	expression tag
Phe 682	-	expression tag
Gln 683	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	302990.6
All*	Total formula weight	302990.6

*Water molecules are not included.