5DFP
Crystal structure of PAK1 in complex with an inhibitor compound FRAX1036
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase PAK 1 | polymer | 297 | 33367.2 | 1 | UniProt (Q13153) Pfam (PF00069) | Homo sapiens (Human) | Alpha-PAK,p21-activated kinase 1,PAK-1,p65-PAK |
| 2 | B (A) | 6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-8-ethyl-2-{[2-(1-methylpiperidin-4-yl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one | non-polymer | 518.1 | 1 | Chemie (59U) | |||
| 3 | C (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 4 | D (A) | water | water | 18.0 | 203 | Chemie (HOH) |
Sequence modifications
A: 249 - 545 (UniProt: Q13153)
| PDB | External Database | Details |
|---|---|---|
| Arg 299 | Lys 299 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33367.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 596.2 | |
| All* | Total formula weight | 33963.4 |
