5DDA
Menin in complex with MI-333
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Menin | polymer | 489 | 54570.2 | 1 | UniProt (O00255) Pfam (PF05053) In PDB | Homo sapiens (Human) | |
2 | A | 4-{4-[5-(fluoromethyl)-1,3,4-thiadiazol-2-yl]piperazin-1-yl}-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine | non-polymer | 418.4 | 1 | Chemie (59M) | |||
3 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 4 | Chemie (DMS) | |||
4 | A | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
5 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
6 | A | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
7 | water | water | 18.0 | 266 | Chemie (HOH) |
Sequence modifications
A: 1 - 459 (UniProt: O00255)
A: 537 - 593 (UniProt: O00255)
PDB | External Database | Details |
---|---|---|
Gly -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
- | Ile 54 | deletion |
- | Pro 55 | deletion |
- | Thr 56 | deletion |
- | Asn 57 | deletion |
- | Val 58 | deletion |
- | Pro 59 | deletion |
- | Glu 60 | deletion |
- | Leu 61 | deletion |
- | Thr 62 | deletion |
- | Phe 63 | deletion |
- | Gln 64 | deletion |
- | Pro 65 | deletion |
- | Ser 66 | deletion |
- | Pro 67 | deletion |
- | Ala 68 | deletion |
- | Pro 69 | deletion |
- | Asp 70 | deletion |
- | Pro 71 | deletion |
- | Pro 72 | deletion |
- | Gly 73 | deletion |
- | Glu 387 | deletion |
- | Glu 388 | deletion |
- | Arg 389 | deletion |
- | Pro 390 | deletion |
- | Gly 391 | deletion |
- | Glu 392 | deletion |
- | Gln 393 | deletion |
- | Ser 394 | deletion |
- | Gln 395 | deletion |
- | Gly 396 | deletion |
- | Thr 397 | deletion |
- | Gln 398 | deletion |
PDB | External Database | Details |
---|---|---|
Ala 541 | Thr 541 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 54570.2 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 1573.7 | |
All* | Total formula weight | 56143.9 |