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5DC8

Crystal structure of H142A-Y306F HDAC8 in complex with a tetrapeptide substrate

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BHistone deacetylase 8polymer38943148.92UniProt (Q9BY41)
Pfam (PF00850)
In PDB
Homo sapiens (Human)HD8
2C, DFluor-de-Lys tetrapeptide assay substratepolymer6837.02synthetic construct
3A, BZINC IONnon-polymer65.42Chemie (ZN)
4A, BPOTASSIUM IONnon-polymer39.14Chemie (K)
5B, CGLYCEROLnon-polymer92.12Chemie (GOL)
6waterwater18.0830Chemie (HOH)
Sequence modifications
A, B: 1 - 377 (UniProt: Q9BY41)
PDBExternal DatabaseDetails
Ala 142His 142engineered mutation
Phe 306Tyr 306engineered mutation
Ile 378-expression tag
Glu 379-expression tag
Gly 380-expression tag
Arg 381-expression tag
Gly 382-expression tag
Ser 383-expression tag
His 384-expression tag
His 385-expression tag
His 386-expression tag
His 387-expression tag
His 388-expression tag
His 389-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight87971.8
Non-Polymers*Number of molecules8
Total formula weight471.4
All*Total formula weight88443.2
*Water molecules are not included.

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PDB entries from 2024-07-31

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