5DAF
Crystal Structure of Human KEAP1 BTB Domain in Complex with Small Molecule TX64063
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Kelch-like ECH-associated protein 1 | polymer | 140 | 15595.0 | 1 | UniProt (Q14145) Pfam (PF00651) | Homo sapiens (Human) | Cytosolic inhibitor of Nrf2,INrf2,Kelch-like protein 19 |
| 2 | B (A) | (5aS,6S,9aS)-7-hydroxy-2,6,9a-trimethyl-3-(pyridin-3-yl)-4,5,5a,6,9,9a-hexahydro-2H-benzo[g]indazole-8-carbonitrile | non-polymer | 334.4 | 1 | Chemie (58E) | |||
| 3 | C (A) | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
A: 49 - 182 (UniProt: Q14145)
| PDB | External Database | Details |
|---|---|---|
| Gly 43 | - | expression tag |
| Ser 44 | - | expression tag |
| His 45 | - | expression tag |
| Met 46 | - | expression tag |
| Ala 47 | - | expression tag |
| Ser 48 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 15595.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 334.4 | |
| All* | Total formula weight | 15929.4 |
