5D9Q
Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122 and scFv NIH45-46
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | G, A, J | Envelope glycoprotein gp120 | polymer | 472 | 52862.8 | 3 | UniProt (Q2N0S6) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | |
2 | B, C, K | Envelope glycoprotein gp41 | polymer | 152 | 17031.4 | 3 | UniProt (Q2N0S9) Pfam (PF00517) UniProt (by SIFTS) (Q2N0S6) In PDB | Human immunodeficiency virus 1 | |
3 | L, E, M | PGT122 light chain,Ig lambda-3 chain C regions | polymer | 211 | 22712.1 | 3 | UniProt (P0CG06) In PDB | Homo sapiens | |
4 | H, F, N | PGT122 heavy chain,IgG H chain | polymer | 235 | 25448.7 | 3 | UniProt (S6B291) Pfam (PF07686) Pfam (PF07654) In PDB | Homo sapiens | |
5 | D, I, O | NIH45-46 single chain Fv | polymer | 241 | 26304.2 | 3 | Homo sapiens | ||
6 | d, f, j, P, R... | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 9 | In PDB GlyTouCan (G22768VO) | |||
7 | e, Q, s | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G81315DD) | |||
8 | a, b, 1, c, 2... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 18 | In PDB GlyTouCan (G42666HT) | |||
9 | h, l, T, v, X... | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 6 | In PDB GlyTouCan (G55220VL) | |||
10 | i, U, w | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1883.7 | 3 | In PDB GlyTouCan (G60230HH) | |||
11 | 0, m, Y | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1721.5 | 3 | In PDB GlyTouCan (G91704UR) | |||
12 | G, B, A, C, J... | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 18 | Chemie (NAG) |
Sequence modifications
G, A, J: 31 - 504 (UniProt: Q2N0S6)
B, C, K: 512 - 663 (UniProt: Q2N0S9)
L, E, M: 8 - 108 (PDB: 5D9Q)
L, E, M: 109 - 213 (UniProt: P0CG06)
H, F, N: 1 - 106 (PDB: 5D9Q)
H, F, N: 107 - 214 (UniProt: S6B291)
PDB | External Database | Details |
---|---|---|
Asn 332 | Thr 330 | conflict |
Ala 460 | Ser 457 | conflict |
Asn 461 | Thr 458 | conflict |
Thr 463 | Ser 460 | conflict |
Ser 464 | Thr 461 | conflict |
Cys 501 | Ala 498 | conflict |
PDB | External Database | Details |
---|---|---|
Pro 559 | Ile 558 | conflict |
Cys 605 | Thr 604 | conflict |
L, E, M: 109 - 213 (UniProt: P0CG06)
PDB | External Database | Details |
---|---|---|
Val 156 | Ala 49 | conflict |
H, F, N: 107 - 214 (UniProt: S6B291)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 15 |
Total formula weight | 433077.7 | |
Branched | Number of molecules | 42 |
Total formula weight | 36308.9 | |
Non-Polymers* | Number of molecules | 18 |
Total formula weight | 3981.7 | |
All* | Total formula weight | 473368.3 |