5D5K

Crystal Structure NLS from human PARP-2 complexed with Importin alpha delta IBB

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	C	Importin subunit alpha-1	polymer	466	50461.3	1	UniProt (P52293) Pfam (PF01749) Pfam (PF00514) Pfam (PF16186) In PDB	Mus musculus (Mouse)	Importin alpha P1,Karyopherin subunit alpha-2,Pendulin,Pore targeting complex 58 kDa subunit,PTAC58,RAG cohort protein 1,SRP1-alpha
2	B	Poly [ADP-ribose] polymerase 2	polymer	98	10773.2	1	UniProt (Q9UGN5) In PDB	Homo sapiens (Human)	hPARP-2,ADP-ribosyltransferase diphtheria toxin-like 2,ARTD2,NAD(+) ADP-ribosyltransferase 2,ADPRT-2,Poly[ADP-ribose] synthase 2,pADPRT-2
3		water	water		18.0	324	Chemie (HOH)

Sequence modifications

C: 70 - 529 (UniProt: P52293)

PDB	External Database	Details
Met 64	-	initiating methionine
Ala 65	-	expression tag
Asp 66	-	expression tag
Ile 67	-	expression tag
Gly 68	-	expression tag
Ser 69	-	expression tag

B: 0 - 77 (UniProt: Q9UGN5)

PDB	External Database	Details
Met -20	-	initiating methionine
Gly -19	-	expression tag
Ser -18	-	expression tag
Ser -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Leu -7	-	expression tag
Val -6	-	expression tag
Pro -5	-	expression tag
Arg -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	61234.4
All*	Total formula weight	61234.4

*Water molecules are not included.