5D48

Crystal Structure of FABP4 in complex with 3-{5-cyclopropyl-3-(3,5-dimethyl-1H-pyrazol-4-yl)-2-[3-(propan-2-yloxy) phenyl]-1H-indol-1-yl}propanoic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Fatty acid-binding protein, adipocyte	polymer	152	16911.3	1	UniProt (P15090) Pfam (PF00061)	Homo sapiens (Human)	Adipocyte lipid-binding protein,ALBP,Adipocyte-type fatty acid-binding protein,AFABP,Fatty acid-binding protein 4
2	B (A)	3-{5-cyclopropyl-3-(3,5-dimethyl-1H-pyrazol-4-yl)-2-[3-(propan-2-yloxy)phenyl]-1H-indol-1-yl}propanoic acid	non-polymer		457.6	1	Chemie (L96)
3	C, D (A)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
4	E (A)	water	water		18.0	86	Chemie (HOH)

Sequence modifications

A: 0 - 131 (UniProt: P15090)

PDB	External Database	Details
Met -20	-	expression tag
Gly -19	-	expression tag
Ser -18	-	expression tag
Ser -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Leu -7	-	expression tag
Val -6	-	expression tag
Pro -5	-	expression tag
Arg -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	16911.3
Non-Polymers*	Number of molecules	3
	Total formula weight	647.5
All*	Total formula weight	17558.8

*Water molecules are not included.