5D3R
First bromodomain of BRD4 bound to inhibitor XD42
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Bromodomain-containing protein 4 | polymer | 127 | 15099.4 | 1 | UniProt (O60885) Pfam (PF00439) In PDB | Homo sapiens (Human) | Protein HUNK1 |
2 | A | 4-acetyl-N-[3-(azepan-1-ylsulfonyl)phenyl]-5-methyl-3-propyl-1H-pyrrole-2-carboxamide | non-polymer | 445.6 | 1 | Chemie (57C) | |||
3 | water | water | 18.0 | 65 | Chemie (HOH) |
Sequence modifications
A: 42 - 168 (UniProt: O60885)
PDB | External Database | Details |
---|---|---|
Met 43 | Thr 43 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 15099.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 445.6 | |
All* | Total formula weight | 15545.0 |