5D3N
First bromodomain of BRD4 bound to inhibitor XD40
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Bromodomain-containing protein 4 | polymer | 126 | 15012.3 | 1 | UniProt (O60885) Pfam (PF00439) In PDB | Homo sapiens (Human) | Protein HUNK1 |
| 2 | A | 4-acetyl-3-ethyl-5-methyl-N-[2-methyl-5-(methylsulfamoyl)phenyl]-1H-pyrrole-2-carboxamide | non-polymer | 377.5 | 1 | Chemie (L40) | |||
| 3 | water | water | 18.0 | 62 | Chemie (HOH) |
Sequence modifications
A: 43 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Met 43 | Thr 43 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 15012.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 377.5 | |
| All* | Total formula weight | 15389.8 |
