5CZK
Structure of E. coli beta-glucuronidase bound with a novel, potent inhibitor 1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-hydroxyethyl)-3-(4-hydroxyphenyl)thiourea
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Beta-glucuronidase | polymer | 605 | 69356.6 | 2 | UniProt (P05804) Pfam (PF02837) Pfam (PF00703) Pfam (PF02836) | Escherichia coli | GUS,Beta-D-glucuronoside glucuronosohydrolase |
| 2 | C, D (A, B) | 1-[(6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-1-(2-hydroxyethyl)-3-(4-hydroxyphenyl)thiourea | non-polymer | 397.5 | 2 | Chemie (57Z) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 407 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 603 (UniProt: P05804)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 138713.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 795.0 | |
| All* | Total formula weight | 139508.2 |
