5CXZ
SYK catalytic domain complexed with naphthyridine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tyrosine-protein kinase SYK | polymer | 289 | 33669.8 | 1 | UniProt (P43405) Pfam (PF07714) In PDB | Homo sapiens (Human) | Spleen tyrosine kinase,p72-Syk |
| 2 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 3 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | A | N-{7-[4-(dimethylamino)phenyl]-1,6-naphthyridin-5-yl}propane-1,3-diamine | non-polymer | 321.4 | 1 | Chemie (55U) | |||
| 5 | water | water | 18.0 | 138 | Chemie (HOH) |
Sequence modifications
A: 356 - 635 (UniProt: P43405)
| PDB | External Database | Details |
|---|---|---|
| Met 353 | - | initiating methionine |
| Ala 354 | - | expression tag |
| Leu 355 | - | expression tag |
| Thr 467 | Lys 467 | engineered mutation |
| His 636 | - | expression tag |
| His 637 | - | expression tag |
| His 638 | - | expression tag |
| His 639 | - | expression tag |
| His 640 | - | expression tag |
| His 641 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33669.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 449.0 | |
| All* | Total formula weight | 34118.7 |
