5CX9
Crystal structure of CK2alpha with (methyl 4-((3-(3-chloro-4-(phenyl)benzylamino)propyl)amino)-4-oxobutanoate bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Casein kinase II subunit alpha | polymer | 352 | 41467.8 | 2 | UniProt (P68400) Pfam (PF00069) | Homo sapiens (Human) | CK II alpha |
| 2 | C, D, E, F, K... (A, B) | ACETATE ION | non-polymer | 59.0 | 6 | Chemie (ACT) | |||
| 3 | G, H, I, M, N (A, B) | methyl 3-[(3-{[(2-chlorobiphenyl-4-yl)methyl]amino}propyl)amino]-3-oxopropanoate | non-polymer | 374.9 | 5 | Chemie (551) | |||
| 4 | J (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 5 | O, P (A, B) | water | water | 18.0 | 313 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 329 (UniProt: P68400)
| PDB | External Database | Details |
|---|---|---|
| Gly -22 | - | expression tag |
| Ser -21 | - | expression tag |
| Met -20 | - | expression tag |
| Asp -19 | - | expression tag |
| Ile -18 | - | expression tag |
| Glu -17 | - | expression tag |
| Phe -16 | - | expression tag |
| Asp -15 | - | expression tag |
| Asp -14 | - | expression tag |
| Asp -13 | - | expression tag |
| Ala -12 | - | expression tag |
| Asp -11 | - | expression tag |
| Asp -10 | - | expression tag |
| Asp -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Ser -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Ser -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Ser 21 | Arg 21 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 82935.6 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2323.5 | |
| All* | Total formula weight | 85259.1 |
