5CVD

Crystal structure of human NRMT1 in complex with alpha-N-dimethylated human CENP-A peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	N-terminal Xaa-Pro-Lys N-methyltransferase 1	polymer	243	27589.4	2	UniProt (Q9BV86) Pfam (PF05891)	Homo sapiens (Human)	Alpha N-terminal protein methyltransferase 1A,Methyltransferase-like protein 11A,N-terminal RCC1 methyltransferase,X-Pro-Lys N-terminal protein methyltransferase 1A,NTM1A
2	C, D (D, E)	N-teminal peptide from Histone H3-like centromeric protein A	polymer	9	1142.4	2	UniProt (P49450)	Homo sapiens (Human)	Centromere autoantigen A,Centromere protein A,CENP-A
3	E, F (A, B)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH)
4	G, H, I, J (A, B, D, E)	water	water		18.0	727	Chemie (HOH)

Sequence modifications

A, B: 1 - 223 (UniProt: Q9BV86)

PDB	External Database	Details
Met -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	57463.6
Non-Polymers*	Number of molecules	2
	Total formula weight	768.8
All*	Total formula weight	58232.4

*Water molecules are not included.