5CUH
Crystal structure MMP-9 complexes with a constrained hydroxamate based inhibitor LT4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Matrix metalloproteinase-9,Matrix metalloproteinase-9 | polymer | 164 | 18338.3 | 2 | UniProt (P14780) Pfam (PF00413) | Homo sapiens (Human) | MMP-9,92 kDa gelatinase,92 kDa type IV collagenase,Gelatinase B,GELB,MMP-9,92 kDa gelatinase,92 kDa type IV collagenase,Gelatinase B,GELB |
| 2 | C, D, L, M (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | E, F, G, N, O... (A, B) | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 4 | H, Q (A, B) | (4S)-3-{[4-(4-cyano-2-methylphenyl)piperazin-1-yl]sulfonyl}-N-hydroxy-1,3-thiazolidine-4-carboxamide | non-polymer | 411.5 | 2 | Chemie (LTQ) | |||
| 5 | I, J, R, S (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 6 | K, U (A, B) | S-1,2-PROPANEDIOL | non-polymer | 76.1 | 2 | Chemie (PGO) | |||
| 7 | T (B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 8 | V, W (A, B) | water | water | 18.0 | 366 | Chemie (HOH) |
Sequence modifications
A, B: 107 - 216 (UniProt: P14780)
A, B: 217 - 269 (UniProt: P14780)
| PDB | External Database | Details |
|---|---|---|
| Gly 106 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36676.6 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 1803.7 | |
| All* | Total formula weight | 38480.3 |
