5CSW
B-RAF in complex with Dabrafenib
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Serine/threonine-protein kinase B-raf | polymer | 282 | 32029.7 | 2 | UniProt (P15056) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1 |
2 | A, B | Dabrafenib | non-polymer | 519.6 | 2 | Chemie (P06) | |||
3 | B | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
4 | water | water | 18.0 | 16 | Chemie (HOH) |
Sequence modifications
A, B: 442 - 721 (UniProt: P15056)
PDB | External Database | Details |
---|---|---|
Pro 443 | Arg 443 | engineered mutation |
Ala 543 | Ile 543 | engineered mutation |
Ser 544 | Ile 544 | engineered mutation |
Lys 551 | Ile 551 | engineered mutation |
Arg 562 | Gln 562 | engineered mutation |
Asn 588 | Leu 588 | engineered mutation |
Ser 630 | Lys 630 | engineered mutation |
Glu 667 | Phe 667 | engineered mutation |
Ser 673 | Tyr 673 | engineered mutation |
Arg 688 | Ala 688 | engineered mutation |
Ser 706 | Leu 706 | engineered mutation |
Arg 709 | Gln 709 | engineered mutation |
Glu 713 | Ser 713 | engineered mutation |
Glu 716 | Leu 716 | engineered mutation |
Glu 720 | Ser 720 | engineered mutation |
Ser 722 | - | expression tag |
Gly 723 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 64059.4 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1074.6 | |
All* | Total formula weight | 65134.0 |