5CQ2

Crystal Structure of tandem WW domains of ITCH in complex with TXNIP peptide

Replaces:  4ROH

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	E3 ubiquitin-protein ligase Itchy homolog	polymer	90	10412.4	1	UniProt (Q96J02) Pfam (PF00397) In PDB	Homo sapiens (Human)	Itch,Atrophin-1-interacting protein 4,AIP4,NFE2-associated polypeptide 1,NAPP1
2	B, C	Thioredoxin-interacting protein	polymer	14	1359.6	2	UniProt (Q9H3M7) In PDB	Homo sapiens	Thioredoxin-binding protein 2,Vitamin D3 up-regulated protein 1
3	A, B, C	UNKNOWN ATOM OR ION	non-polymer			18	Chemie (UNX)
4		water	water		18.0	55	Chemie (HOH)

Sequence modifications

A: 433 - 521 (UniProt: Q96J02)

PDB	External Database	Details
Gly 432	-	expression tag

B, C: 327 - 338 (UniProt: Q9H3M7)

PDB	External Database	Details
Ace 326	-	acetylation
Nh2 339	-	amidation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	13131.6
Non-Polymers*	Number of molecules	18
	Total formula weight	0.0
All*	Total formula weight	13131.6

*Water molecules are not included.