5COQ
The effect of valine to alanine mutation on InhA enzyme crystallization pattern and substrate binding loop conformation and flexibility
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Enoyl-[acyl-carrier-protein] reductase [NADH] | polymer | 289 | 30698.1 | 4 | UniProt (M9TGV3) Pfam (PF13561) UniProt (by SIFTS) (P9WGR1) In PDB | Mycobacterium tuberculosis | |
2 | A, B, C, D | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 4 | Chemie (NAD) | |||
3 | A, B, C, D | 5-HEXYL-2-(2-METHYLPHENOXY)PHENOL | non-polymer | 284.4 | 4 | Chemie (TCU) | |||
4 | C | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
5 | water | water | 18.0 | 328 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 269 (UniProt: M9TGV3)
PDB | External Database | Details |
---|---|---|
Met -19 | - | initiating methionine |
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
Ser -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
Gly -7 | - | expression tag |
Leu -6 | - | expression tag |
Val -5 | - | expression tag |
Pro -4 | - | expression tag |
Arg -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
Ala 203 | Val 203 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 122792.3 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 3814.3 | |
All* | Total formula weight | 126606.6 |