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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5CGH

Yeast 20S proteasome beta5-G48C mutant in complex with alpha-chloroacetamide 5

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, OProteasome subunit alpha type-2polymer25027191.82UniProt (P23639)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae S288CMacropain subunit Y7,Multicatalytic endopeptidase complex subunit Y7,Proteasome component Y7,Proteinase YSCE subunit 7
2B, PProteasome subunit alpha type-3polymer25828748.22UniProt (P23638)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae S288CMacropain subunit Y13,Multicatalytic endopeptidase complex subunit Y13,Proteasome component Y13,Proteinase YSCE subunit 13
3C, QProteasome subunit alpha type-4polymer25428478.12UniProt (P40303)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae S288CMacropain subunit PRE6,Multicatalytic endopeptidase complex subunit PRE6,Proteasome component PRE6,Proteinase YSCE subunit PRE6
4D, RProteasome subunit alpha type-5polymer26028649.12UniProt (P32379)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae S288CMacropain subunit PUP2,Multicatalytic endopeptidase complex subunit PUP2,Proteasome component PUP2,Proteinase YSCE subunit PUP2
5E, SProteasome subunit alpha type-6polymer23425634.02UniProt (P40302)
Pfam (PF00227)
Pfam (PF10584)
In PDB		Saccharomyces cerevisiae S288CMacropain subunit PRE5,Multicatalytic endopeptidase complex subunit PRE5,Proteasome component PRE5,Proteinase YSCE subunit PRE5
6F, TProbable proteasome subunit alpha type-7polymer28831575.12UniProt (P21242)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae S288CMacropain subunit C1,Multicatalytic endopeptidase complex subunit C1,Proteasome component C1,Proteinase YSCE subunit 1
7G, UProteasome subunit alpha type-1polymer25228033.82UniProt (P21243)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae S288CMacropain subunit C7-alpha,Multicatalytic endopeptidase complex C7,Proteasome component C7-alpha,Proteasome component Y8,Proteinase YSCE subunit 7,SCL1 suppressor protein
8H, VProteasome subunit beta type-2polymer23225114.52UniProt (P25043)
Pfam (PF00227)
Pfam (PF12465)
In PDB		Saccharomyces cerevisiae S288CMacropain subunit PUP1,Multicatalytic endopeptidase complex subunit PUP1,Proteasome component PUP1,Proteinase YSCE subunit PUP1
9I, WProteasome subunit beta type-3polymer20522627.82UniProt (P25451)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae S288CMacropain subunit PUP3,Multicatalytic endopeptidase complex subunit PUP3,Proteasome component PUP3
10J, XProteasome subunit beta type-4polymer19822545.72UniProt (P22141)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae S288CMacropain subunit C11,Multicatalytic endopeptidase complex subunit C11,Proteasome component C11,Proteinase YSCE subunit 11
11K, YProteasome subunit beta type-5polymer21223371.32UniProt (P30656)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae S288CMacropain subunit PRE2,Multicatalytic endopeptidase complex subunit PRE2,Proteasome component PRE2,Proteinase YSCE subunit PRE2
12L, ZProteasome subunit beta type-6polymer22224883.92UniProt (P23724)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae S288CMulticatalytic endopeptidase complex subunit C5,Proteasome component C5
13M, aProteasome subunit beta type-7polymer24627200.92UniProt (P30657)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae S288CMacropain subunit PRE4,Multicatalytic endopeptidase complex subunit PRE4,Proteasome component PRE4,Proteinase YSCE subunit PRE4
14N, bProteasome subunit beta type-1polymer19621517.22UniProt (P38624)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae S288CMacropain subunit PRE3,Multicatalytic endopeptidase complex subunit PRE3,Proteasome component PRE3,Proteinase YSCE subunit PRE3
15c, gcarfilzomib-alpha-chloroacetamide 5polymer5544.12synthetic construct
16G, I, K, N, V...MAGNESIUM IONnon-polymer24.37Chemie (MG)
17G, UCHLORIDE IONnon-polymer35.52Chemie (CL)
18K, Y2-(N-MORPHOLINO)-ETHANESULFONIC ACIDnon-polymer195.22Chemie (MES)
19c, gpent-4-ynoic acidnon-polymer98.12Chemie (54L)
20waterwater18.01125Chemie (HOH)
Sequence modifications
K, Y: 1 - 212 (UniProt: P30656)
PDBExternal DatabaseDetails
Cys 48Gly 123conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains30
Total formula weight732231.1
Non-Polymers*Number of molecules13
Total formula weight827.7
All*Total formula weight733058.8
*Water molecules are not included.

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PDB entries from 2024-08-07

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