5CFB

Crystal Structure of Human Glycine Receptor alpha-3 Bound to Strychnine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E (A, B, C, D, E)	Glycine receptor subunit alpha-3,Glycine receptor subunit alpha-3	polymer	362	41857.4	5	UniProt (O75311) Pfam (PF02931) Pfam (PF02932)	Homo sapiens (Human)
2	F, G (F, G)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
3	H, K, L, M, N (A, B, C, D, E)	STRYCHNINE	non-polymer		334.4	5	Chemie (SY9)
4	I, J, O (A, B, E)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)

Sequence modifications

A, B, C, D, E: 1 - 309 (UniProt: O75311)
A, B, C, D, E: 313 - 354 (UniProt: O75311)

PDB	External Database	Details
Ala 310	-	linker
Gly 311	-	linker
Thr 312	-	linker
Trp 355	-	expression tag
Ser 356	-	expression tag
His 357	-	expression tag
Pro 358	-	expression tag
Gln 359	-	expression tag
Phe 360	-	expression tag
Glu 361	-	expression tag
Lys 362	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	209287.0
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	8
	Total formula weight	2335.7
All*	Total formula weight	212471.5

*Water molecules are not included.