5CCL
Crystal structure of SMYD3 with SAM and oxindole compound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone-lysine N-methyltransferase SMYD3 | polymer | 432 | 49673.6 | 1 | UniProt (Q9H7B4) Pfam (PF00856) Pfam (PF01753) | Homo sapiens (Human) | SET and MYND domain-containing protein 3,Zinc finger MYND domain-containing protein 1 |
| 2 | B, C, D (A) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 3 | E (A) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) | |||
| 4 | F, G (A) | 2-oxidanylidene-N-piperidin-4-yl-1,3-dihydroindole-5-carboxamide | non-polymer | 259.3 | 2 | Chemie (4ZW) | |||
| 5 | H (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | I (A) | water | water | 18.0 | 449 | Chemie (HOH) |
Sequence modifications
A: 1 - 428 (UniProt: Q9H7B4)
| PDB | External Database | Details |
|---|---|---|
| Asn 13 | Lys 13 | conflict |
| Phe 429 | - | expression tag |
| Sec 430 | - | expression tag |
| Leu 431 | - | expression tag |
| Leu 432 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 49673.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1175.3 | |
| All* | Total formula weight | 50849.0 |
