5C7K
Crystal structure BG505 SOSIP gp140 HIV-1 Env trimer bound to broadly neutralizing antibodies PGT128 and 8ANC195
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Antibody Fab PGT128 heavy chain | polymer | 239 | 25580.7 | 1 | UniProt (S6B291) Pfam (PF07686) Pfam (PF07654) In PDB | Homo sapiens | |
2 | B | Antibody Fab PGT128 light chain | polymer | 211 | 22223.6 | 1 | UniProt (C6KXN3) In PDB | Homo sapiens | |
3 | C | Envelope glycoprotein gp120 | polymer | 487 | 54596.7 | 1 | UniProt (Q2N0S6) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | |
4 | D | Envelope glycoprotein gp41 | polymer | 153 | 17146.5 | 1 | UniProt (Q2N0S6) Pfam (PF00517) In PDB | Human immunodeficiency virus 1 | |
5 | E | Antibody Fab 8ANC195 heavy chain | polymer | 238 | 25268.4 | 1 | UniProt (P01857) Pfam (PF07654) In PDB | Homo sapiens | |
6 | F | Antibody Fab 8ANC195 light chain | polymer | 215 | 23402.0 | 1 | UniProt (P01834) Pfam (PF07654) In PDB | Homo sapiens | |
7 | G, H, I, J | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
8 | K, M | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1559.4 | 2 | In PDB GlyTouCan (G68668TB) | |||
9 | L | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1721.5 | 1 | In PDB GlyTouCan (G40702WU) | |||
10 | N | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G46836GH) | |||
11 | O | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G42227JK) | |||
12 | P, Q, R | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
13 | S | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 1 | In PDB GlyTouCan (G34499SX) | |||
14 | T | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1883.7 | 1 | In PDB GlyTouCan (G60230HH) | |||
15 | D, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
16 | C | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) |
Sequence modifications
A: 1 - 105 (PDB: 5C7K)
A: 106 - 231 (UniProt: S6B291)
B: 1 - 97 (PDB: 5C7K)
B: 98 - 215 (UniProt: C6KXN3)
C: 31 - 510 (UniProt: Q2N0S6)
D: 512 - 664 (UniProt: Q2N0S6)
E: 1 - 113 (PDB: 5C7K)
E: 114 - 219 (UniProt: P01857)
F: 1 - 108 (PDB: 5C7K)
F: 109 - 214 (UniProt: P01834)
A: 106 - 231 (UniProt: S6B291)
B: 1 - 97 (PDB: 5C7K)
B: 98 - 215 (UniProt: C6KXN3)
C: 31 - 510 (UniProt: Q2N0S6)
PDB | External Database | Details |
---|---|---|
Arg 30 | - | expression tag |
Asn 332 | Thr 330 | engineered mutation |
Cys 501 | Ala 498 | engineered mutation |
Ser 508 | Arg 505 | engineered mutation |
Ser 511 | - | expression tag |
Gly 512 | - | expression tag |
His 513 | - | expression tag |
His 514 | - | expression tag |
His 515 | - | expression tag |
His 516 | - | expression tag |
His 517 | - | expression tag |
His 518 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Pro 559 | Ile 556 | engineered mutation |
Cys 605 | Thr 602 | engineered mutation |
E: 114 - 219 (UniProt: P01857)
F: 1 - 108 (PDB: 5C7K)
F: 109 - 214 (UniProt: P01834)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 168217.8 | |
Branched | Number of molecules | 14 |
Total formula weight | 13724.4 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1423.3 | |
All* | Total formula weight | 183365.5 |