5C6B
Crystal Structure of Prefusion-stabilized RSV F variant SC-TM
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (F) | Fusion glycoprotein F0,Fibritin | polymer | 497 | 54712.3 | 1 | UniProt (P03420) UniProt (Q38650) Pfam (PF00523) | Human respiratory syncytial virus A | Protein F |
| 2 | B (F) | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID | non-polymer | 207.3 | 1 | Chemie (NHE) | |||
| 3 | C, D, E, F (F) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | G, H (F) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | I (F) | water | water | 18.0 | 161 | Chemie (HOH) |
Sequence modifications
F: 26 - 513 (UniProt: P03420)
F: 518 - 544 (UniProt: Q38650)
| PDB | External Database | Details |
|---|---|---|
| Lys 66 | Glu 66 | conflict |
| Ile 67 | Asn 67 | engineered mutation |
| Ile 76 | Val 76 | conflict |
| Ala 102 | Pro 102 | conflict |
| Gln 128 | Arg 106 | conflict |
| - | Arg 109 | deletion |
| - | Glu 110 | deletion |
| - | Leu 111 | deletion |
| - | Pro 112 | deletion |
| - | Arg 113 | deletion |
| - | Phe 114 | deletion |
| - | Met 115 | deletion |
| - | Asn 116 | deletion |
| - | Tyr 117 | deletion |
| - | Thr 118 | deletion |
| - | Leu 119 | deletion |
| - | Asn 120 | deletion |
| - | Asn 121 | deletion |
| - | Ala 122 | deletion |
| - | Lys 123 | deletion |
| - | Lys 124 | deletion |
| - | Thr 125 | deletion |
| - | Asn 126 | deletion |
| - | Val 127 | deletion |
| - | Thr 128 | deletion |
| - | Leu 129 | deletion |
| - | Ser 130 | deletion |
| Gly 131 | Lys 131 | linker |
| Ser 132 | Lys 132 | linker |
| Gly 133 | Arg 133 | linker |
| Ser 134 | Lys 134 | linker |
| Gly 135 | Arg 135 | linker |
| Ser 137 | Phe 137 | conflict |
| Pro 215 | Ser 215 | engineered mutation |
| Val 379 | Ile 379 | engineered mutation |
| Val 447 | Met 447 | engineered mutation |
| Gln 487 | Glu 487 | conflict |
| Ser 514 | - | linker |
| Ala 515 | - | linker |
| Ile 516 | - | linker |
| Gly 517 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 54712.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 662.4 | |
| All* | Total formula weight | 55374.7 |
