5C2H

PDE10 complexed with 6-chloro-N-[(2,4-dimethylthiazol-5-yl)methyl]-5-methyl-2-[3-(2-quinolyl)propoxy]pyrimidin-4-amine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	polymer	362	41495.5	2	UniProt (Q9Y233) In PDB	Homo sapiens (Human)
2	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	A	3-(1-hydroxy-2-methylpropan-2-yl)-5-phenyl-3,5-dihydro-1H-imidazo[4,5-c][1,8]naphthyridine-2,4-dione	non-polymer		350.4	1	Chemie (4PX)
5	B	6-chloro-N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-5-methyl-2-[3-(quinolin-2-yl)propoxy]pyrimidin-4-amine	non-polymer		454.0	1	Chemie (4XU)
6		water	water		18.0	62	Chemie (HOH)

Sequence modifications

A, B: 439 - 779 (UniProt: Q9Y233)

PDB	External Database	Details
Met 418	-	initiating methionine
Gly 419	-	expression tag
Ser 420	-	expression tag
Ser 421	-	expression tag
His 422	-	expression tag
His 423	-	expression tag
His 424	-	expression tag
His 425	-	expression tag
His 426	-	expression tag
His 427	-	expression tag
Ser 428	-	expression tag
Ser 429	-	expression tag
Gly 430	-	expression tag
Leu 431	-	expression tag
Val 432	-	expression tag
Pro 433	-	expression tag
Arg 434	-	expression tag
Gly 435	-	expression tag
Ser 436	-	expression tag
His 437	-	expression tag
Met 438	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	82991.0
Non-Polymers*	Number of molecules	6
	Total formula weight	983.8
All*	Total formula weight	83974.8

*Water molecules are not included.