5C26
Crystal structure of SYK in complex with compound 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase SYK | polymer | 299 | 35040.9 | 1 | UniProt (P43405) Pfam (PF07714) | Homo sapiens (Human) | Spleen tyrosine kinase,p72-Syk |
| 2 | B (B) | GLU-VAL-PTR-GLU-SER-PRO | polymer | 6 | 802.7 | 1 | Homo sapiens (Human) | ||
| 3 | C (A) | 3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzamide | non-polymer | 389.4 | 1 | Chemie (50H) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 183 | Chemie (HOH) |
Sequence modifications
A: 343 - 635 (UniProt: P43405)
| PDB | External Database | Details |
|---|---|---|
| His 636 | - | expression tag |
| His 637 | - | expression tag |
| His 638 | - | expression tag |
| His 639 | - | expression tag |
| His 640 | - | expression tag |
| His 641 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35843.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 389.4 | |
| All* | Total formula weight | 36233.1 |
