5C0R
Crystal Structure of a Generation 3 Influenza Hemagglutinin Stabilized Stem Complexed with the Broadly Neutralizing Antibody C179
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Hemagglutinin, Envelope glycoprotein, Fibritin fusion protein | polymer | 305 | 34416.1 | 1 | UniProt (Q6WG00) UniProt (P04578) UniProt (D9IEJ2) Pfam (PF00509) In PDB | Influenza A virus Human immunodeficiency virus type 1 group M subtype B Enterobacteria phage T4 | |
| 2 | L | C179 Fab light chain | polymer | 214 | 23451.9 | 1 | Mus musculus | ||
| 3 | H | C179 Fab heavy chain | polymer | 233 | 25062.3 | 1 | Mus musculus | ||
| 4 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 6 | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A: 1 - 32 (UniProt: Q6WG00)
A: 36 - 107 (UniProt: Q6WG00)
A: 110 - 136 (UniProt: P04578)
A: 143 - 174 (UniProt: P04578)
A: 175 - 256 (UniProt: Q6WG00)
A: 260 - 287 (UniProt: D9IEJ2)
A: 36 - 107 (UniProt: Q6WG00)
| PDB | External Database | Details |
|---|---|---|
| Gly 33 | - | linker |
| Trp 34 | - | linker |
| Gly 35 | - | linker |
| Gln 47 | Ser 339 | conflict |
| Arg 47 | Ile 340 | conflict |
| Glu 47 | Gln 341 | conflict |
| Thr 47 | Ser 342 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ile 123 | Leu 641 | conflict |
| Tyr 125 | His 643 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asn 137 | - | linker |
| Gly 138 | - | linker |
| Thr 139 | - | linker |
| Gly 140 | - | linker |
| Gly 141 | - | linker |
| Gly 142 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 108 | - | linker |
| Gly 109 | - | linker |
| Pro 257 | - | linker |
| Gly 258 | - | linker |
| Ser 259 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 288 | - | expression tag |
| Arg 289 | - | expression tag |
| Leu 290 | - | expression tag |
| Val 291 | - | expression tag |
| Pro 292 | - | expression tag |
| Arg 293 | - | expression tag |
| Gly 294 | - | expression tag |
| Ser 295 | - | expression tag |
| Gly 296 | - | expression tag |
| His 297 | - | expression tag |
| His 298 | - | expression tag |
| His 299 | - | expression tag |
| His 300 | - | expression tag |
| His 301 | - | expression tag |
| His 302 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 82930.3 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 83575.9 |
