5C03

Crystal Structure of kinase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Non-receptor tyrosine-protein kinase TYK2	polymer	342	38475.5	2	UniProt (P29597) Pfam (PF07714) In PDB	Homo sapiens (Human)
2	A, B	PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER	non-polymer		523.2	2	Chemie (AGS)
3	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	A, B	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)
5	A, B	1,2-ETHANEDIOL	non-polymer		62.1	6	Chemie (EDO)
6		water	water		18.0	298	Chemie (HOH)

Sequence modifications

A, B: 556 - 871 (UniProt: P29597)

PDB	External Database	Details
Met 530	-	expression tag
Ser 531	-	expression tag
Tyr 532	-	expression tag
Tyr 533	-	expression tag
His 534	-	expression tag
His 535	-	expression tag
His 536	-	expression tag
His 537	-	expression tag
His 538	-	expression tag
His 539	-	expression tag
Asp 540	-	expression tag
Tyr 541	-	expression tag
Asp 542	-	expression tag
Ile 543	-	expression tag
Pro 544	-	expression tag
Thr 545	-	expression tag
Thr 546	-	expression tag
Glu 547	-	expression tag
Asn 548	-	expression tag
Leu 549	-	expression tag
Tyr 550	-	expression tag
Phe 551	-	expression tag
Gln 552	-	expression tag
Gly 553	-	expression tag
Ala 554	-	expression tag
Met 555	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	76951.1
Non-Polymers*	Number of molecules	15
	Total formula weight	1928.0
All*	Total formula weight	78879.0

*Water molecules are not included.