5C03
Crystal Structure of kinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Non-receptor tyrosine-protein kinase TYK2 | polymer | 342 | 38475.5 | 2 | UniProt (P29597) Pfam (PF07714) | Homo sapiens (Human) | |
| 2 | C, K (A, B) | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | non-polymer | 523.2 | 2 | Chemie (AGS) | |||
| 3 | D, L (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E, H, I, M, Q (A, B) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 5 | F, G, J, N, O... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 6 | R, S (A, B) | water | water | 18.0 | 298 | Chemie (HOH) |
Sequence modifications
A, B: 556 - 871 (UniProt: P29597)
| PDB | External Database | Details |
|---|---|---|
| Met 530 | - | expression tag |
| Ser 531 | - | expression tag |
| Tyr 532 | - | expression tag |
| Tyr 533 | - | expression tag |
| His 534 | - | expression tag |
| His 535 | - | expression tag |
| His 536 | - | expression tag |
| His 537 | - | expression tag |
| His 538 | - | expression tag |
| His 539 | - | expression tag |
| Asp 540 | - | expression tag |
| Tyr 541 | - | expression tag |
| Asp 542 | - | expression tag |
| Ile 543 | - | expression tag |
| Pro 544 | - | expression tag |
| Thr 545 | - | expression tag |
| Thr 546 | - | expression tag |
| Glu 547 | - | expression tag |
| Asn 548 | - | expression tag |
| Leu 549 | - | expression tag |
| Tyr 550 | - | expression tag |
| Phe 551 | - | expression tag |
| Gln 552 | - | expression tag |
| Gly 553 | - | expression tag |
| Ala 554 | - | expression tag |
| Met 555 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 76951.1 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1928.0 | |
| All* | Total formula weight | 78879.0 |
