5BZX
Crystal structure of human phosphatase PTEN treated with a bisperoxovanadium complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | polymer | 314 | 37307.8 | 4 | UniProt (P60484) Pfam (PF22785) Pfam (PF10409) | Homo sapiens (Human) | Mutated in multiple advanced cancers 1,Phosphatase and tensin homolog |
| 2 | E, H (A, C) | VANADATE ION | non-polymer | 114.9 | 2 | Chemie (VO4) | |||
| 3 | F, G, I (B, C, D) | L(+)-TARTARIC ACID | non-polymer | 150.1 | 3 | Chemie (TLA) | |||
| 4 | J, K, L, M (A, B, C, D) | water | water | 18.0 | 880 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 14 - 351 (UniProt: P60484)
| PDB | External Database | Details |
|---|---|---|
| - | Thr 286 | deletion |
| - | Ser 287 | deletion |
| - | Glu 288 | deletion |
| - | Lys 289 | deletion |
| - | Val 290 | deletion |
| - | Glu 291 | deletion |
| - | Asn 292 | deletion |
| - | Gly 293 | deletion |
| - | Ser 294 | deletion |
| - | Leu 295 | deletion |
| - | Cys 296 | deletion |
| - | Asp 297 | deletion |
| - | Gln 298 | deletion |
| - | Glu 299 | deletion |
| - | Ile 300 | deletion |
| - | Asp 301 | deletion |
| - | Ser 302 | deletion |
| - | Ile 303 | deletion |
| - | Cys 304 | deletion |
| - | Ser 305 | deletion |
| - | Ile 306 | deletion |
| - | Glu 307 | deletion |
| - | Arg 308 | deletion |
| - | Ala 309 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 149231.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 680.1 | |
| All* | Total formula weight | 149911.4 |
