5BS0
MAGE-A3 Reactive TCR in complex with Titin Epitope in HLA-A1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA class I histocompatibility antigen, A-1 alpha chain | polymer | 275 | 31734.1 | 1 | UniProt (P30443) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439) | Homo sapiens (Human) | MHC class I antigen A*1 |
| 2 | B (B) | Beta-2-microglobulin | polymer | 100 | 11879.4 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (Human) | |
| 3 | C (C) | Titin | polymer | 9 | 1021.1 | 1 | UniProt (Q8WZ42) | Homo sapiens | Connectin,Rhabdomyosarcoma antigen MU-RMS-40.14 |
| 4 | D (D) | Protein TRAV21,T-cell receptor alpha chain C region | polymer | 197 | 21451.9 | 1 | UniProt (A0A0B4J279) UniProt (P01848) Pfam (PF07686) Pfam (PF09291) | Homo sapiens (Human) | |
| 5 | E (E) | Protein TRBV5-1,Human nkt tcr beta chain | polymer | 241 | 27132.1 | 1 | UniProt (A0A578) UniProt (K7N5M4) Pfam (PF07686) Pfam (PF07654) UniProt (by SIFTS) (A0A5B9) | Homo sapiens (Human) | V_segment translation product |
| 6 | F (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | G, H, I, J, K... (A, B, D, E) | SULFATE ION | non-polymer | 96.1 | 11 | Chemie (SO4) | |||
| 8 | R, S, T (A, D, E) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A: 1 - 274 (UniProt: P30443)
B: 1 - 99 (UniProt: P61769)
D: 3 - 94 (UniProt: A0A0B4J279)
D: 117 - 198 (UniProt: P01848)
E: 3 - 95 (UniProt: A0A578)
E: 102 - 243 (UniProt: K7N5M4)
| PDB | External Database | Details |
|---|---|---|
| Pro 275 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Ala 2 | - | expression tag |
| Tyr 50 | Leu 68 | conflict |
| Val 51 | Ile 69 | conflict |
| Arg 52 | Gln 70 | conflict |
| Pro 53 | Ser 71 | conflict |
| Tyr 54 | Ser 72 | conflict |
| Pro 95 | - | linker |
| Gly 96 | - | linker |
| Gly 97 | - | linker |
| Ala 98 | - | linker |
| Gly 99 | - | linker |
| Pro 100 | - | linker |
| Phe 101 | - | linker |
| Phe 102 | - | linker |
| Val 103 | - | linker |
| Val 104 | - | linker |
| Phe 105 | - | linker |
| Gly 106 | - | linker |
| Lys 107 | - | linker |
| Gly 108 | - | linker |
| Thr 109 | - | linker |
| Lys 110 | - | linker |
| Leu 111 | - | linker |
| Ser 112 | - | linker |
| Val 113 | - | linker |
| Ile 114 | - | linker |
| Pro 115 | - | linker |
| Asn 116 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Cys 163 | Thr 49 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Phe 96 | - | linker |
| Asn 97 | - | linker |
| Met 98 | - | linker |
| Ala 99 | - | linker |
| Thr 100 | - | linker |
| Gly 101 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Asp 202 | Asn 208 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 93218.5 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1148.8 | |
| All* | Total formula weight | 94367.3 |
