5BRX
X-ray crystal structure of Aplysia californica (Ac-AChBP) in complex with 2-pyridyl azatricyclo[3.3.1.13,7]decane; 2-pyridylazaadamantane; 2-Aza (TI-8480)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Soluble acetylcholine receptor | polymer | 230 | 26235.1 | 10 | UniProt (Q8WSF8) Pfam (PF02931) | Aplysia californica (California sea hare) | |
| 2 | BA, K, L, O, P... (I, A, B, C, D...) | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
| 3 | CA, M, S, W (I, A, D, F) | (2R,3S,5R,7S)-2-(pyridin-3-yl)-1-azatricyclo[3.3.1.1~3,7~]decane | non-polymer | 214.3 | 4 | Chemie (TI4) | |||
| 4 | AA, DA, N, Q, T... (H, J, A, C, E...) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 6 | Chemie (PG4) | |||
| 5 | EA, FA, GA, HA, IA... (A, B, C, D, E...) | water | water | 18.0 | 525 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J: 1 - 219 (UniProt: Q8WSF8)
| PDB | External Database | Details |
|---|---|---|
| Asp -8 | - | expression tag |
| Tyr -7 | - | expression tag |
| Lys -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Lys -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Trp 55 | Tyr 72 | engineered mutation |
| Ser 220 | - | expression tag |
| Arg 221 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 262351.4 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 2983.2 | |
| All* | Total formula weight | 265334.6 |
