5BRV
Catalytic Improvement of an Artificial Metalloenzyme by Computational Design
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Carbonic anhydrase 2 | polymer | 260 | 29292.1 | 1 | UniProt (P00918) Pfam (PF00194) In PDB | Homo sapiens (Human) | Carbonate dehydratase II,Carbonic anhydrase C,CAC,Carbonic anhydrase II,CA-II |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | pentamethylcyclopentadienyl iridium [N-benzensulfonamide-(2-pyridylmethyl-4-benzensulfonamide)amin] chloride | non-polymer | 765.4 | 1 | Chemie (9TH) | |||
4 | water | water | 18.0 | 146 | Chemie (HOH) |
Sequence modifications
A: 3 - 260 (UniProt: P00918)
PDB | External Database | Details |
---|---|---|
Met 1 | - | initiating methionine |
Ala 2 | - | expression tag |
Met 140 | Leu 140 | engineered mutation |
Met 197 | Leu 197 | engineered mutation |
Ser 205 | Cys 205 | engineered mutation |
Leu 252 | Asn 252 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 29292.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 830.8 | |
All* | Total formula weight | 30122.9 |