5BRN
Human HGPRT in complex with (S)-HPEPHx, an acyclic nucleoside phosphonate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Hypoxanthine-guanine phosphoribosyltransferase | polymer | 218 | 24516.2 | 4 | UniProt (P00492) Pfam (PF00156) | Homo sapiens (Human) | HGPRTase |
| 2 | E, G, I, K (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 3 | F, H, J, L (A, B, C, D) | (2-{[(2S)-1-hydroxy-3-(6-oxo-1,6-dihydro-9H-purin-9-yl)propan-2-yl]oxy}ethyl)phosphonic acid | non-polymer | 318.2 | 4 | Chemie (4X2) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 265 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 0 - 217 (UniProt: P00492)
| PDB | External Database | Details |
|---|---|---|
| Ala 22 | Cys 23 | engineered mutation |
| Ala 105 | Cys 106 | engineered mutation |
| Ala 205 | Cys 206 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 98064.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1370.1 | |
| All* | Total formula weight | 99435.0 |
