5BRD
Crystal structure of Trypanosoma cruzi glucokinase in complex with inhibitor BENZ-GlcN
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glucokinase 1, putative | polymer | 381 | 42226.6 | 2 | UniProt (Q4E4E1) Pfam (PF02685) | Trypanosoma cruzi (strain CL Brener) | |
| 2 | C, D (A, B) | 2-(benzoylamino)-2-deoxy-beta-D-glucopyranose | non-polymer | 283.3 | 2 | Chemie (BG8) PubChem (253013) PubChem (10423943) PubChem (10589017) PubChem (21677942) PubChem (71191323) PubChem (27506902) PubChem (27506904) PubChem (46783646) PubChem (27506903) PubChem (10423941) PubChem (58852881) PubChem (168358810) PubChem (168372924) PubChem (90352172) PubChem (90352714) PubChem (90352715) PubChem (92238235) PubChem (92238236) PubChem (95162085) PubChem (124200295) PubChem (124200400) PubChem (124636762) PubChem (124795543) PubChem (125459835) PubChem (131700285) PubChem (133126697) PubChem (134554133) PubChem (140874695) PubChem (141569347) PubChem (168358020) PubChem (168363549) PubChem (168364842) PubChem (168376567) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 87 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 367 (UniProt: Q4E4E1)
| PDB | External Database | Details |
|---|---|---|
| Met -13 | - | initiating methionine |
| Gly -12 | - | expression tag |
| Arg -11 | - | expression tag |
| Gly -10 | - | expression tag |
| Ser -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Met -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 84453.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 566.6 | |
| All* | Total formula weight | 85019.9 |
