5BQQ
Human insulin with intra-chain chemical crosslink between modified B27 and B30
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G, I... (A, C, E, G, I...) | Insulin | polymer | 21 | 2383.7 | 6 | UniProt (P01308) | Homo sapiens | |
| 2 | B, D, F, H, J... (B, D, F, H, J...) | Insulin | polymer | 30 | 3396.9 | 6 | UniProt (P01308) | Homo sapiens | |
| 3 | M, P, S, T, U... (A, C, E, G, H...) | PHENOL | non-polymer | 94.1 | 10 | Chemie (IPH) | |||
| 4 | N, Q (B, D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | O, R (B, D) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | AA, BA, CA, DA, EA... (A, B, C, D, E...) | water | water | 18.0 | 375 | Chemie (HOH) |
Sequence modifications
B, D, F, H, J, L: 1 - 28 (UniProt: P01308)
| PDB | External Database | Details |
|---|---|---|
| Nva 27 | Thr 51 | engineered mutation |
| Gly 29 | - | expression tag |
| Hix 30 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 34683.4 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1142.8 | |
| All* | Total formula weight | 35826.3 |
