5BO7

Structure of human sialyltransferase ST8SiaIII in complex with CTP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase	polymer	323	37919.0	2	UniProt (O43173) Pfam (PF00777)	Homo sapiens (Human)	Alpha-2,8-sialyltransferase 8C,8-sialyltransferase III,ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3,Sialyltransferase 8C,SIAT8-C,Sialyltransferase St8Sia III,ST8SiaIII
2	C, D, F, G, H... (C, D, F, G, H...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	6	In PDB GlyTouCan (G42666HT)
3	E (E)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	1	In PDB GlyTouCan (G21290RB)
4	J, L (A, B)	CYTIDINE-5'-TRIPHOSPHATE	non-polymer		483.2	2	Chemie (CTP)
5	K (B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
6	M, N (A, B)	water	water		18.0	364	Chemie (HOH)

Sequence modifications

A, B: 81 - 380 (UniProt: O43173)

PDB	External Database	Details
Ala 58	-	expression tag
Pro 59	-	expression tag
Glu 60	-	expression tag
His 61	-	expression tag
His 62	-	expression tag
His 63	-	expression tag
His 64	-	expression tag
His 65	-	expression tag
His 66	-	expression tag
Asp 67	-	expression tag
Tyr 68	-	expression tag
Asp 69	-	expression tag
Ile 70	-	expression tag
Pro 71	-	expression tag
Thr 72	-	expression tag
Thr 73	-	expression tag
Glu 74	-	expression tag
Asn 75	-	expression tag
Leu 76	-	expression tag
Tyr 77	-	expression tag
Phe 78	-	expression tag
Gln 79	-	expression tag
Gly 80	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	75838.0
Branched	Number of molecules	7
	Total formula weight	3116.9
Non-Polymers*	Number of molecules	3
	Total formula weight	1187.5
All*	Total formula weight	80142.5

*Water molecules are not included.