5BO4

Structure of SOCS2:Elongin C:Elongin B from DMSO-treated crystals

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J, M... (A, D, G, J, M...)	Suppressor of cytokine signaling 2	polymer	169	19377.3	6	UniProt (O14508) Pfam (PF00017) Pfam (PF07525)	Homo sapiens (Human)	SOCS-2,Cytokine-inducible SH2 protein 2,CIS-2,STAT-induced STAT inhibitor 2,SSI-2
2	B, E, H, K, N... (B, E, H, K, N...)	Transcription elongation factor B polypeptide 2	polymer	104	11852.4	6	UniProt (Q15370) Pfam (PF00240)	Homo sapiens (Human)	Elongin 18 kDa subunit,Elongin-B,EloB,RNA polymerase II transcription factor SIII subunit B,SIII p18
3	C, F, I, L, O... (C, F, I, L, O...)	Transcription elongation factor B polypeptide 1	polymer	97	10974.6	6	UniProt (Q15369) Pfam (PF03931)	Homo sapiens (Human)	Elongin 15 kDa subunit,Elongin-C,EloC,RNA polymerase II transcription factor SIII subunit C,SIII p15
4	AA, S, T, U, V... (R, A, D, F, G...)	water	water		18.0	33	Chemie (HOH)

Sequence modifications

A, D, G, J, M, P: 32 - 198 (UniProt: O14508)

PDB	External Database	Details
Ser 30	-	expression tag
Met 31	-	expression tag

C, F, I, L, O, R: 17 - 112 (UniProt: Q15369)

PDB	External Database	Details
Met 16	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	18
	Total formula weight	253225.5
All*	Total formula weight	253225.5

*Water molecules are not included.