5BML
ROCK 1 bound to a pyridine thiazole inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Rho-associated protein kinase 1 | polymer | 415 | 48012.3 | 2 | UniProt (Q13464) Pfam (PF00069) | Homo sapiens (Human) | Renal carcinoma antigen NY-REN-35,Rho-associated,coiled-coil-containing protein kinase 1,coiled-coil-containing protein kinase I,ROCK-I,p160 ROCK-1,p160ROCK |
| 2 | C, D (A, B) | N-[4-(2-fluoropyridin-4-yl)thiophen-2-yl]-2-{3-[(methylsulfonyl)amino]phenyl}acetamide | non-polymer | 405.5 | 2 | Chemie (4TW) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 48 | Chemie (HOH) |
Sequence modifications
A, B: 6 - 415 (UniProt: Q13464)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Ser 2 | - | expression tag |
| Leu 3 | - | expression tag |
| His 4 | - | expression tag |
| Met 5 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 96024.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 810.9 | |
| All* | Total formula weight | 96835.5 |
