5B8C
High resolution structure of the human PD-1 in complex with pembrolizumab Fv
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D, G, J | Pembrolizumab light chain variable region (PemVL) | polymer | 119 | 12991.5 | 4 | Homo sapiens | ||
2 | B, E, H, K | Pembrolizumab heavy chain variable region (PemVH) | polymer | 120 | 13495.0 | 4 | Homo sapiens | ||
3 | C, F, I, L | Programmed cell death protein 1 | polymer | 139 | 15514.2 | 4 | UniProt (Q15116) Pfam (PF07686) In PDB | Homo sapiens (Human) | hPD-1 |
4 | water | water | 18.0 | 271 | Chemie (HOH) |
Sequence modifications
C, F, I, L: 32 - 160 (UniProt: Q15116)
PDB | External Database | Details |
---|---|---|
Gly 30 | - | expression tag |
Ser 31 | - | expression tag |
Ser 93 | Cys 93 | engineered mutation |
Thr 161 | - | expression tag |
Ser 162 | - | expression tag |
Glu 163 | - | expression tag |
Asn 164 | - | expression tag |
Leu 165 | - | expression tag |
Tyr 166 | - | expression tag |
Phe 167 | - | expression tag |
Gln 168 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 168002.5 | |
All* | Total formula weight | 168002.5 |