5B8C
High resolution structure of the human PD-1 in complex with pembrolizumab Fv
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G, J (A, D, G, J) | Pembrolizumab light chain variable region (PemVL) | polymer | 119 | 12991.5 | 4 | Homo sapiens | ||
| 2 | B, E, H, K (B, E, H, K) | Pembrolizumab heavy chain variable region (PemVH) | polymer | 120 | 13495.0 | 4 | Homo sapiens | ||
| 3 | C, F, I, L (C, F, I, L) | Programmed cell death protein 1 | polymer | 139 | 15514.2 | 4 | UniProt (Q15116) Pfam (PF07686) | Homo sapiens (Human) | hPD-1 |
| 4 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 271 | Chemie (HOH) |
Sequence modifications
C, F, I, L: 32 - 160 (UniProt: Q15116)
| PDB | External Database | Details |
|---|---|---|
| Gly 30 | - | expression tag |
| Ser 31 | - | expression tag |
| Ser 93 | Cys 93 | engineered mutation |
| Thr 161 | - | expression tag |
| Ser 162 | - | expression tag |
| Glu 163 | - | expression tag |
| Asn 164 | - | expression tag |
| Leu 165 | - | expression tag |
| Tyr 166 | - | expression tag |
| Phe 167 | - | expression tag |
| Gln 168 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 168002.5 | |
| All* | Total formula weight | 168002.5 |
