5B2M

A crucial role of Cys218 in the stabilization of an unprecedented auto-inhibition form of MAP2K7

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Dual specificity mitogen-activated protein kinase kinase 7	polymer	324	36998.9	1	UniProt (O14733) Pfam (PF00069)	Homo sapiens (Human)	MAPKK 7,JNK-activating kinase 2,MAPK/ERK kinase 7,MEK 7,Stress-activated protein kinase kinase 4,SAPKK4,c-Jun N-terminal kinase kinase 2,JNKK 2
2	B (A)	water	water		18.0	10	Chemie (HOH)

Sequence modifications

A: 119 - 435 (UniProt: O14733)

PDB	External Database	Details
Met 118	-	initiating methionine
His 436	-	expression tag
His 437	-	expression tag
His 438	-	expression tag
His 439	-	expression tag
His 440	-	expression tag
His 441	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36998.9
All*	Total formula weight	36998.9

*Water molecules are not included.