5B16
X-ray structure of DROSHA in complex with the C-terminal tail of DGCR8.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Ribonuclease 3,DROSHA,Ribonuclease 3,DROSHA,Ribonuclease 3 | polymer | 986 | 108687.4 | 1 | UniProt (Q9NRR4) Pfam (PF14622) Pfam (PF00636) Pfam (PF00035) | Homo sapiens (Human) | Protein Drosha,Ribonuclease III,RNase III,p241,Protein Drosha,Ribonuclease III,RNase III,p241,Protein Drosha,Ribonuclease III,RNase III,p241 |
| 2 | B, C (B, C) | Microprocessor complex subunit DGCR8 | polymer | 39 | 4591.3 | 2 | UniProt (Q8WYQ5) | Homo sapiens (Human) | DiGeorge syndrome critical region 8 |
| 3 | D, E (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) |
Sequence modifications
A: 411 - 458 (UniProt: Q9NRR4)
A: 459 - 521 (PDB: 5B16)
A: 522 - 711 (UniProt: Q9NRR4)
A: 712 - 849 (PDB: 5B16)
A: 850 - 1365 (UniProt: Q9NRR4)
B, C: 728 - 750 (UniProt: Q8WYQ5)
| PDB | External Database | Details |
|---|---|---|
| Met 388 | - | initiating methionine |
| Ala 389 | - | expression tag |
| Lys 390 | - | expression tag |
| Glu 391 | - | expression tag |
| Pro 392 | - | expression tag |
| Glu 393 | - | expression tag |
| Glu 394 | - | expression tag |
| Thr 395 | - | expression tag |
| Met 396 | - | expression tag |
| Pro 397 | - | expression tag |
| Asp 398 | - | expression tag |
| Lys 399 | - | expression tag |
| Asn 400 | - | expression tag |
| Glu 401 | - | expression tag |
| Glu 402 | - | expression tag |
| Glu 403 | - | expression tag |
| Glu 404 | - | expression tag |
| Glu 405 | - | expression tag |
| Glu 406 | - | expression tag |
| Leu 407 | - | expression tag |
| Leu 408 | - | expression tag |
| Lys 409 | - | expression tag |
| Pro 410 | - | expression tag |
A: 522 - 711 (UniProt: Q9NRR4)
A: 712 - 849 (PDB: 5B16)
A: 850 - 1365 (UniProt: Q9NRR4)
| PDB | External Database | Details |
|---|---|---|
| Gln 1045 | Glu 1045 | engineered mutation |
| Gln 1222 | Glu 1222 | engineered mutation |
| Ser 1366 | - | expression tag |
| Arg 1367 | - | expression tag |
| Leu 1368 | - | expression tag |
| Glu 1369 | - | expression tag |
| Val 1370 | - | expression tag |
| Leu 1371 | - | expression tag |
| Phe 1372 | - | expression tag |
| Gln 1373 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 726 | - | initiating methionine |
| Ala 727 | - | expression tag |
| His 751 | - | expression tag |
| Gly 752 | - | expression tag |
| Gly 753 | - | expression tag |
| Ser 754 | - | expression tag |
| Arg 755 | - | expression tag |
| Gly 756 | - | expression tag |
| Asp 757 | - | expression tag |
| Met 758 | - | expression tag |
| Leu 759 | - | expression tag |
| Glu 760 | - | expression tag |
| Val 761 | - | expression tag |
| Leu 762 | - | expression tag |
| Phe 763 | - | expression tag |
| Gln 764 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 117869.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 130.8 | |
| All* | Total formula weight | 118000.7 |
