5AX3
Crystal structure of ERK2 complexed with allosteric and ATP-competitive inhibitors.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 1 | polymer | 368 | 42231.4 | 1 | UniProt (P28482) Pfam (PF00069) | Homo sapiens (Human) | MAPK 1,ERT1,Extracellular signal-regulated kinase 2,ERK-2,MAP kinase isoform p42,p42-MAPK,Mitogen-activated protein kinase 2,MAPK 2 |
| 2 | B (B) | allosteric and ATP-competitive inhibitor | polymer | 12 | 1491.8 | 1 | UniProt (by SIFTS) (P40763) | Homo sapiens | |
| 3 | C (A) | (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL | non-polymer | 392.1 | 1 | Chemie (5ID) PubChem (16760523) PubChem (1830) PubChem (97297) PubChem (23919584) PubChem (25880707) PubChem (26248662) PubChem (35028380) PubChem (46875276) PubChem (51386958) PubChem (51537014) PubChem (45039587) PubChem (59583554) PubChem (59583625) PubChem (6419781) PubChem (9886793) PubChem (14221929) PubChem (134695308) |
Sequence modifications
A: -8 - 350 (UniProt: P28482)
| PDB | External Database | Details |
|---|---|---|
| Gly -16 | - | expression tag |
| Asp -15 | - | expression tag |
| Leu -14 | - | expression tag |
| Gly -13 | - | expression tag |
| Ser -12 | - | expression tag |
| Asp -11 | - | expression tag |
| Glu -10 | - | expression tag |
| Leu -9 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43723.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 392.1 | |
| All* | Total formula weight | 44115.4 |
