5AR5

RIP2 Kinase Catalytic Domain (1 - 310) complex with Benzimidazole

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2	polymer	326	37606.0	2	UniProt (O43353) Pfam (PF07714)	HOMO SAPIENS (HUMAN)	CARD-CONTAINING INTERLEUKIN-1 BETA-CONVERTING ENZYME-ASSOCIATED KINASE, CARD-CONTAINING IL-1 BETA ICE-KINASE, RIP-LIKE-INTERACTING CLARP KINASE, RECEPTOR-INTERACTING PROTEIN 2, RIP-2, TYROSINE-PROTEIN KINASE RIPK2
2	C (A)	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
3	D, E (A, B)	2-(2-(4-CHLOROPHENYL)-1H-IMIDAZOL-5-YL)-N,1-BIS(2-METHOXYETHYL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXAMIDE	non-polymer		453.9	2	Chemie (IQ7)
4	F, G (A, B)	water	water		18.0	272	Chemie (HOH)

Sequence modifications

A, B: 1 - 310 (UniProt: O43353)

PDB	External Database	Details
Met -15	-	expression tag
Asp -14	-	expression tag
Tyr -13	-	expression tag
Lys -12	-	expression tag
Asp -11	-	expression tag
Asp -10	-	expression tag
Asp -9	-	expression tag
Asp -8	-	expression tag
Lys -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	75212.0
Non-Polymers*	Number of molecules	3
	Total formula weight	947.9
All*	Total formula weight	76159.9

*Water molecules are not included.